Two sample MR report
TAGLN_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0667755 | 0.2953986 | 0.8322419 |
| Weighted median | 6 | -0.0684724 | 0.0153018 | 0.0000076 |
| Inverse variance weighted | 6 | -0.0721601 | 0.0116875 | 0.0000000 |
| Simple mode | 6 | -0.0676479 | 0.0209293 | 0.0231491 |
| Weighted mode | 6 | -0.0675833 | 0.0219888 | 0.0276723 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1480430 | 4 | 0.9973919 |
| Inverse variance weighted | 0.3696025 | 5 | 0.9961257 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1597895 | 0.3394712 | 0.6623746 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.74e-05 | 0 | TRUE | 0.5698947 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
